The Seropositivity Rate of Human Cytomegalovirus [Hcmv] Among Hepatitis B Virus [Hbv] Patients, Hepatitis C Virus [Hcv] Patients, and Blood Donors in Diyala Province
DOI:
https://doi.org/10.24237/ASJ.02.01.729BKeywords:
CMV, HCV, HBV, Blood donors, CMV IgM, CMV IgG, LifestyleAbstract
The total number of samples was 112 that collected from 31 patients with hepatitis B virus [11 females and 20 males], 31 patients with hepatitis C virus [10 females and 21 males], and 50 males of blood donors during the period from the 1st of January, 2022, to the 1st of May, 2022. The samples were screened routinely for hepatitis C, hepatitis B virus, HIV, and Syphilis but not for HCMV. The goal of this research was to assess the incidence of HCMV IgG and HCMV IgM seropositivity in blood donors, HCV patients, and HBV patients in Diyala province using an enzyme-linked immunosorbent assay [ELISA]. The results revealed that the seropositivity of HCMV IgM was 3.2% in each of the HCV and HBV patients and 0.0% in blood donors. In contrast, the seropositivity of HCMV IgG was high among all study groups which were 96.8% among HCV patients, 100% among HBV patients, and 92% among blood donors. Based on the lifestyle, the percentage of HCMV IgM seropositivity for urban participants was 1.6%, and for rural participants, 2.0%. Meanwhile, the seropositivity of HCMV IgG was 96.7% in urban participants and 94.1% in rural participants.
References
Gugliesi, F., Coscia, A., Griffante, G., Galitska, G., Pasquero, S., Albano, C., & Biolatti, M. [2020]. Where do we stand after decades of studying human cytomegalovirus?. Microorganisms, 8[5], 685.
Shragai, T., Lebel, E., Deshet, D., Varon, D., Avivi, I., Kirgner, I., & Sarid, N. [2020]. Characteristics and outcomes of adults with cytomegalovirus‐associated thrombocytopenia: a case series and literature review. British Journal of Haematology, 191[5], 863-867.
Mahallawi, W., Khabour, O. F., Al-Saedi, A., Almuzaini, Z., & Ibrahim, N. [2022]. Human Cytomegalovirus Seroprevalence Among Blood Donors in the Madinah Region, Saudi Arabia. Cureus, 14[2].
Lazzaro, A., Vo, M. L., Zeltzer, J., Rawlinson, W., Nassar, N., Daly, K., ... & Shand, A. [2019]. Knowledge of congenital cytomegalovirus [CMV] in pregnant women in Australia is low, and improved with education. Australian and New Zealand Journal of Obstetrics and Gynaecology, 59[6], 843-849.
Bernshtein, B., Nachshon, A., Shnayder, M., Stern, L., Avdic, S., Blyth, E., ... & Schwartz, M. [2021]. Profiling the blood compartment of hematopoietic stem cell transplant patients during human cytomegalovirus reactivation. Frontiers in cellular and infection microbiology, 10, 607470.
Nanakaly, H. T., & Hussen, B. M. [2019]. Seroprevalence of Cytomegalovirus Among Voluntary Blood Donors in Erbil Province, North Iraq. Zanco Journal of Pure and Applied Sciences, 31[3], 1-6.
Voruz, S., Gowland, P., Eyer, C., Widmer, N., Abonnenc, M., Prudent, M., & Niederhauser, C. [2020]. Transfusion-transmitted cytomegalovirus: behaviour of cell-free virus during blood component processing. A study on the safety of labile blood components in Switzerland. Blood transfusion, 18[6], 446.
Mandal, S., Kumar, R., Parwan, D., Singh, N., Sharma, R., & Das, B. [2022]. Seroprevalence of transfusion-transmissible infections among blood donors and their notification: A study from North India. Iraqi Journal of Hematology, 11[1], 65.
DaPalma, T., Doonan, B. P., Trager, N. M., & Kasman, L. M. [2010]. A systematic approach to virus–virus interactions. Virus research, 149[1], 1-9.
Fakhreddine, A. Y., Frenette, C. T., & Konijeti, G. G. [2019]. A practical review of cytomegalovirus in gastroenterology and hepatology. Gastroenterology research and practice, 2019.
Ibrahim, M. K., Khedr, A., Bader El Din, N. G., Khairy, A., & El Awady, M. K. [2017]. Increased incidence of cytomegalovirus coinfection in HCV-infected patients with late liver fibrosis is associated with dysregulation of JAK-STAT pathway. Scientific reports, 7[1], 1-10.
Bader El Din, N. G., Abd El Meguid, M., Tabll, A. A., Anany, M. A., Esmat, G., Zayed, N., ... & El Awady, M. K. [2011]. Human cytomegalovirus infection inhibits response of chronic hepatitis‐C‐virus‐infected patients to interferon‐based therapy. Journal of gastroenterology and hepatology, 26[1], 55-62.
Khan, M. M., Ali, M. J., Hanif, H., Maqsood, M. H., Ahmad, I., Alvarez, J. E., ... & Lau, D. T. [2022]. The dilemma of cytomegalovirus and hepatitis B virus interaction. Gastroenterology Report, 10.
Hu, J., Zhao, H., Lou, D., Gao, H., Yang, M., Zhang, X., ... & Li, L. [2018]. Human cytomegalovirus and Epstein-Barr virus infections, risk factors, and their influence on the liver function of patients with acute-on-chronic liver failure. BMC Infectious Diseases, 18[1], 1-8.
Mistry, N., Richardson, V., Carey, E., Porter, S., Pincus, S., Novins-Montague, S., ... & Anstett, T. [2022]. General Improvements versus Interruptive or Non-interruptive Alerts in the Blood Order Set: study protocol for a randomized control trial to improve packed red blood cell utilization.
Adane, T., & Getawa, S. [2021]. Cytomegalovirus seroprevalence among blood donors: a systematic review and meta-analysis. Journal of International Medical Research, 49[8], 03000605211034656.
Dollard, S. C., Staras, S. A., Amin, M. M., Schmid, D. S., & Cannon, M. J. [2011]. National prevalence estimates for cytomegalovirus IgM and IgG avidity and association between high IgM antibody titer and low IgG avidity. Clinical and vaccine immunology, 18[11], 1895-1899.
Pass, R. F., & Arav-Boger, R. [2018]. Maternal and fetal cytomegalovirus infection: diagnosis, management, and prevention. F1000Research, 7.
Khalid, M. D. [2012]. Prevalence of cytomegalovirus antibodies among blood donors in Mosul Central Blood Bank/Iraq. Google Scholar.
Khudir, M. K., & Molan, A. L. [2014]. Seroprevalence of cytomegalovirus among healthy students at Diyala University, Diyala, Iraq. Journal of Pharmacy an d Biological Sciences, 9, 59-61.
AL-Khilkhali, H. B., Muhsin, M. A., & AL-Saadi, M. A. [2015]. Assessment of Viral load for Human Cytomegalovirus in Patients with Hepatitis B Virus. Al-Kufa University Journal for Biology, 7[3].
Mahallawi, W., Khabour, O. F., Al-Saedi, A., Almuzaini, Z., & Ibrahim, N. [2022]. Human Cytomegalovirus Seroprevalence Among Blood Donors in the Madinah Region, Saudi Arabia. Cureus, 14[2].
Safabakhsh, H., Tehranian, F., Tehranian, B., Hatami, H., Karimi, G., & Shahabi, M. [2013]. Prevalence of anti-CMV antibodies in blood donors in Mashhad, Iran.
Bayram, A., Özkur, A., & Erkilic, S. [2009]. Prevalence of human cytomegalovirus co-infection in patients with chronic viral hepatitis B and C: a comparison of clinical and histological aspects. Journal of clinical virology, 45[3], 212-217.
Mohamed, H., El-Amin, M. M., Abdeen, H., & Fathy, T. [2017]. Cytomegalovirus Infection among Patients with Chronic Hepatitis C Virus and its relation to hepatitis C virus load. Afro-Egyptian Journal of Infectious and Endemic Diseases, 7[3], 102-108.
Naqid, I. A., Yousif, S. H., & Hussein, N. R. [2019]. Serological study of IgG and IgM antibodies to cytomegalovirus and Toxoplasma infections in pregnant women in Zakho city, Kurdistan region, Iraq. Women’s Health Bulletin, 6[4], 8-12.
Gawad, A. A., Hashish, M., Abaza, A., & El-Kayal, A. [2016]. Cytomegalovirus immunoglobulin G avidity index among blood donors in Alexandria, Egypt. Central European Journal of Public Health, 24[4], 314-320.
Abbas, N. A., & Zaman, N. A. [2019]. Serological Study of Human Cytomegalovirus in Thalassemia Patients and Blood Donors and its Relation to IL-6 in Kirkuk City. Rafidain Journal of Science, 28[1], 23-28.
Kowalzik, F., Hitzler, W., Runkel, S., & Marron, M. [2020]. Seroprevalence and seroconversion of cytomegalovirus in a large group of healthy, German blood donors: potential contribution to transfusion transmitted infections. Clin Lab, 66[10.7754].
Ahmed, R. I. [2017]. Detection of Cytomegalovirus Infection in Pre-Marital Women in Al-Khalis City. Diyala Journal For Pure Science, 13[4 -part 1].
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