Relationship the Variation of Serum Vaspin and Some Biochemical Parameters Associated with Gender and BMI of Type2 Diabetic Patients
DOI:
https://doi.org/10.24237/ASJ.02.01.688BKeywords:
T2Diabetes Mellitus, Vaspin, biochemical parameters, gender, BMI.Abstract
Diabetes mellitus is a chronic disorder categorized by rise blood glucose with a disturbance in the use of carbohydrates, fats and proteins resulting from a deficiency in the secretion of the insulin or the action of insulin or both. The current study aimed to estimation of Vaspin and some biochemical parameters included insulin, fasting blood glucose(FBG), HbA1c, urea, creatinine, Triglyceride(TG), Total Cholesterol(TC), High-density lipoprotein (HDL), low density lipoprotein (LDL) and Very low density lipoprotein (VLDL)in blood of type2 diabetic patients, and determining the change of the ratio in patients comparing with healthy people.The serum vaspin level in patients group was significantly lower than that of the healthy subjects (p<0.05). The serum insulin levels in patients were higher than of healthy subjects but without significant differences (p>0.05). There were a significant difference of serum FBG, HbA1c and urea levels in patients compared to controls (p<0.05), while creatinine level was increased non significantly (p>0.05). The levels of TC, TG, LDL and VLDL were elevated significantly in patients when compared with controls (p<0.05), while HDL was diminished non significantly in patients compared to controls. There was no significant links between serum vaspin and insulin concentrations with FBG, HbA1C, CRP, urea, creatinine, TC, TG, LDL, HDL, and VLDL levels. Vaspin had lowest area under curve (AUC 393. ) and sensitivity ( 68.3) in ROC curve.
References
Satish, B. N. V. S., Srikala, P., Maharudrappa, B., Awanti, S. M., Kumar, P., &Hugar, D. (2014). Saliva: A tool in assessing glucose levels in Diabetes Mellitus. Journal of international oral health: JIOH, 6(2), 114.
Law, R. H., Zhang, Q., McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W. Whisstock, J. C. (2006). An overview of the serpin superfamily. Genome biology, 7(5), 1-11.
Hida, K., Wada, J., Eguchi, J., Zhang, H., Baba, M., Seida, A. Kanwar, Y. S. (2005). Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proceedings of the national academy of sciences, 102(30), 10610-10615.
Sezginer, E. K., Kirlangiç, Ö. F., TANRIVERDİ, M. D. E., Topçu, H. O., &Serap, G. Ü. R. (2022). Analysis of changes in serum levels and gene expression profiles of novel adipocytokines (omentin, vaspin, irisin and visfatin) and their correlation with serum C-reactive protein levels in women diagnosed with endometriosis. Turkish Journal of Pharmaceutical Sciences, 19(1), 48.
Shafiei, M. S. (2018). Exposure to alcohol interrupts adipose cell maturation, attenuates adiponectin expression, and contributes to inflammatory markers in 3T3-F442 pre-adipocytes (Doctoral dissertation)30-26.
Alejandro, E. U., Mamerto, T. P., Chung, G., Villavieja, A., Gaus, N. L., Morgan, E., & Pineda-Cortel, M. R. B. (2020). Gestational diabetes mellitus: a harbinger of the vicious cycle of diabetes. International journal of molecular sciences, 21(14), 5003.
Kurowska, P., Mlyczyńska, E., Barbe, A., Staub, C., Gregoraszczuk, E., Dupont, J., & Rak, A. (2019). Vaspin in the pig ovarian follicles: Expression and regulation by different hormones. Reproduction, 158(2), 135-146.
Cox, M. J., Edwards, M. C., Rodriguez Paris, V., Aflatounian, A., Ledger, W. L., Gilchrist, R. B., ... & Walters, K. A. (2020). Androgen action in adipose tissue and the brain are key mediators in the development of PCOS traits in a mouse model. Endocrinology, 161(7).
Feng R, Li Y, Wang C, Luo C, Liu L, Chuo F, Li Q, Sun C (2014). Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: A meta-analysis. Diabetes Res. Clin. Pract, 106: 88–94.
Jeannette Seeger, Michaela Ziegelmeier, Anette Bachmann, Ulrike Lossner, Jurgen Kratzsch, Matthias Bluher, Michael Stumvoll, Mathias Fasshauer(2008). Serum Levels of the Adipokine Vaspin in Relation to Metabolic and Renal Parameters. J Clin. Endocrinol. Metab., 93: 247–251.
Kempf, K., Rose, B., Illig, T., Rathmann, W., Strassburger, K., Thorand, B. Vollmert, C. (2010). Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: results from the MONICA/KORA studies. Experimental and clinical endocrinology & diabetes, 118(03), 184-189.
Ye, Y., Hou, X. H., Pan, X. P., Lu, J. X., & Jia, W. P. (2009). Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes. Chinese medical journal, 122(21), 2530-2533.
Li, K., Li, L., Yang, M., Liu, H., Liu, D., Yang, H. Yang, G. (2011). Short-term continuous subcutaneous insulin infusion decreases the plasma vaspin levels in patients with type 2 diabetes mellitus concomitant with improvement in insulin sensitivity. European journal of endocrinology, 164(6), 905.
Youn, B. S., Kloting, N., Kratzsch, J., Lee, N., Park, J. W., Song, E. S. Bluher, M. (2008). Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes, 57(2), 372-377.
Jian, W., Peng, W., Xiao, S., Li, H., Jin, J., Qin, L. Su, Q. (2014). Role of serum vaspin in progression of type 2 diabetes: a 2-year cohort study. PloS one, 9(4(
Breitfeld, J., Tönjes, A., Böttcher, Y., Schleinitz, D., Wiele, N., Marzi, C. Stumvoll, M. (2013). Genetic variation in the vaspin gene affects circulating serum vaspin concentrations. International Journal of Obesity, 37(6), 861-866.
Auguet, T., Quintero, Y., Riesco, D., Morancho, B., Terra, X., Crescenti, A. Richart, C. (2011). New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC medical genetics, 12(1), 1-8.
Zaoui, S., Biémont, C., &Meguenni, K. (2015). Epidemiology of diabetes in urban and rural regions of Tlemcen (Western Algeria). Cahiers d'étudeset de recherchesfrancophones/Santé, 17(1), 15-21.
Al Shehri, Z. S. (2017). The relationship between some biochemical and hematological changes in type 2 diabetes mellitus. Biomedical Research and Therapy, 4(11), 1760-1774.
Adeboye, B., Bermano, G., & Rolland, C. (2016). Obesity and its health impact in Africa: a systematic review. Cardiovascular journal of Africa, 23(9), 512-521.
Zheng, Y., Ley, S. H., & Hu, F. B. (2018). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature reviews endocrinology, 14(2), 88-98.
Chooi, Y. C., Ding, C., &Magkos, F. (2019). The epidemiology of obesity. Metabolism, 92, 6-10.
Wang, S., Ma, W., Yuan, Z., Wang, S. M., Yi, X., Jia, H., &Xue, F. (2016). Association between obesity indices and type 2 diabetes mellitus among middle-aged and elderly people in Jinan, China: a cross-sectional study. BMJ open, 6(11(.
Xu, Y., Wang, L., He, J., Bi, Y., Li, M., Wang, T. 2010 China Noncommunicable Disease Surveillance Group. (2013). Prevalence and control of diabetes in Chinese adults. Jama, 310(9), 948-959.
Ferdi, N. E. H., Khalida, A. B. L. A., &Chenchouni, H. (2018). Biochemical Profile of an Adult Diabetic Population from Algeria in Relation with Anthropometric Parameters, Age and Gender. Iranian Journal of Public Health, 47(8), 1119.
Das, P., Biswas, S., Mukherjee, S., &Bandyopadhyay, S. K. (2016). Association of oxidative stress and obesity with insulin resistance in type 2 diabetes mellitus. Mymensingh Med J, 25(1), 148-152.
Mehrzad, R. (2020). Definition and introduction to epidemiology of obesity. In Obesity (pp. 1-6).
Amin, M. N., Hussain, M. S., Sarwar, M. S., Moghal, M. M. R., Das, A., Hossain, M. Z. & Islam, M. S. (2019). How the association between obesity and inflammation may lead to insulin resistance and cancer. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(2), 1213-1224.
Gomez-Peralta, F., Abreu, C., Cruz-Bravo, M., Alcarria, E., Gutierrez-Buey, G., Krakauer, N. Y., &Krakauer, J. C. (2018). Relationship between “a body shape index (ABSI)” and body composition in obese patients with type 2 diabetes. Diabetology& metabolic syndrome, 10(1), 1-8.
Bays, H. E., Chapman, R. H., Grandy, S., & SHIELD Investigators’ Group. (2007). The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys. International journal of clinical practice, 61(5), 737-747.
Al Muammar, M. N., & El Shafie, M. (2014). Association between dietary habits and body mass index of adolescent females in intermediate schools in Riyadh, Saudi Arabia. EMHJ-Eastern Mediterranean Health Journal, 20 (1), 39-45.
Alborno, N. T. (2016). serumvaspin level in type 2 diabetic patients from gaza strip.Care, D. (2020). Standards of Medical Care in Diabetesd2020. Diabetes Care, 43, S89.
Gupta, S., & Bansal, S. (2020). Does a rise in BMI cause an increased risk of diabetes Evidence from India. PloS one, 15(4).
Federation, I. D. (2015). IDF Diabetes atlas 9th 30-41.
Al Mansour, M. A. (2020). The prevalence and risk factors of type 2 diabetes mellitus (DMT2) in a semi-urban Saudi population. International journal of environmental research and public health, 17(1), 7.
Yadav, N. K., Thanpari, C., Shrewastwa, M. K., & Mittal, R. K. (2012). Comparison of lipid profile in type-2 obese diabetics and obese non-diabetic individuals. A hospital based study from Western Nepal. Kathmandu University Medical Journal, 10(3), 44-47.
Tahir, A., Martinez, P. J., Ahmad, F., Fisher-Hoch, S. P., McCormick, J., Gay, J. L. Chaudhary, S. U. (2021). An evaluation of lipid profile and pro-inflammatory cytokines as determinants of cardiovascular disease in those with diabetes: a study on a Mexican American cohort (vol 11, 2435, 2021). SCIENTIFIC REPORTS, 11(1).
Thelin, A., & Holmberg, S. (2014). Type 2 Diabetes and Lifestyle—A Prospective Population-Based Cohort Study among Rural Men. Int. J. Diabetes Clin. Res, 1, 2-5.
Beshara, A., Cohen, E., Goldberg, E., Lilos, P., Garty, M., & Krause, I. (2016). Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study. Journal of Investigative Medicine, 64(2), 383-387.
Harder, H., Dinesen, B., &Astrup, A. (2004). The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients. International journal of obesity, 28(1), 180-182.
Yanai, H. (2017). VLDL is the leading actor in lipid abnormality in patients with diabetes and obesity. Journal of Endocrinology and Metabolism, 7(4), 101-102.
Van Herpen, N. A., &Schrauwen-Hinderling, V. B. (2008). Lipid accumulation in non-adipose tissue and lipotoxicity. Physiology & behavior, 94(2), 231-241.
Vajo, Z., Terry, J. G., & Brinton, E. A. (2015). Increased intra-abdominal fat may lower HDL levels by increasing the fractional catabolic rate of Lp AI in postmenopausal women. Atherosclerosis, 160(2), 495-501.
Gastaldelli, A. (2016). Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes research and clinical practice, 93, S60-S65.
Semenkovich, C. F. (2014). Insulin resistance and atherosclerosis. The Journal of clinical investigation, 116(7), 1813-1822.
AL-karkhi, M.H.M. (2022).Estimation of serum free fatty acid and some of biochemical variants in type 2 diabetic patients. Master Thesis, ÇankırıKaratekin University.
Nedyalkova, M., Madurga, S., Ballabio, D., Robeva, R., Romanova, J., Kichev, I., ...&Simeonov, V. (2020). Diabetes mellitus type 2: Exploratory data analysis based on clinical reading. Open Chemistry, 18(1), 1041-1053.
Żyłka, A., Dumnicka, P., Kuśnierz-Cabala, B., Gala-Błądzińska, A., Ceranowicz, P., Kucharz, J., ...&Kuźniewski, M. (2018). Markers of glomerular and tubular damage in the early stage of kidney disease in type 2 diabetic patients. Mediators of Inflammation, 60-52.
Kene, K., Wondimnew, T., Welde, M., Mateos, T., Adugna, T., Gerema, U., ... &Abera, D. (2021). Prevalence and determinants of Impaired Serum Creatinine and Urea among type 2 diabetic patients of jimma medical center, Jimma, Southwestern Ethiopia, 2019. Endocrine and Metabolic Science, 3, 100096.
Higgins, C. (2016). Urea and the clinical value of measuring blood urea concentration. Acutecaretesting. Org, no. August, 1-6.
Chao, G., Zhu, Y., & Chen, L. (2021). Role and Risk Factors of Glycosylated Hemoglobin Levels in Early Disease Screening. Journal of Diabetes Research, 90-78.
Rajput, R., Rajput, M., & Nanda, S. (2012). Utility of HbA1c for diagnosis of gestational diabetes mellitus. Diabetes research and clinical practice, 98(1), 104- 107.
American Diabetes Association. (2020). 5. Facilitating behavior change and well-being to improve health outcomes: Standards of Medical Care in Diabetes—2020. Diabetes Care, 43(Supplement_1), S48-S65.
Kowall, B. (2018). HbA1c target goals in type-2 diabetes: novel arguments from measurement of coronary artery calcification. International journal of cardiology, 266, 256-257.
Silva, J. F., Pimentel, A. L., & Camargo, J. L. (2016). Effect of iron deficiency anaemia on HbA1c levels is dependent on the degree of anaemia. Clinical biochemistry, 49(1-2), 117-120.
Shanak, S., Saad, B., & Zaid, H. (2019). Metabolic and epigenetic action mechanisms of antidiabetic medicinal plants. Evidence-Based Complementary and Alternative Medicine, 30-23.
Aouacheri, O., Saka, S., Krim, M., Messaadia, A., &Maidi, I. (2015). The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus. Canadian journal of diabetes, 39(1), 44-49.
Bhatt, K. N., Pranav, V., Dipika, Y., Dharmesh, N., Radhika, N., & Arvind, S. (2017). Prevalence of nonalcoholic fatty liver disease in type 2 diabetes mellitus and its relation with insulin resistance in South Gujarat Region. Journal of Mahatma Gandhi Institute of Medical Sciences, 22(1), 8.
Kim, N. Y., An, J., Jeong, J. K., Ji, S., Hwang, S. H., Lee, H. S., ...& Kim, Y. (2019). Evaluation of a human glycated hemoglobin test in canine diabetes mellitus. Journal of Veterinary Diagnostic Investigation, 31(3), 408-414.
Czech, M. P. (2017). Insulin action and resistance in obesity and type 2 diabetes. Nature medicine, 23(7), 804-814.
Sathyaseelan, A. J., Adole, P. S., Wyawahare, M., &Saya, R. P. (2016). Assessment of serum vaspin levels among type 2 diabetes mellitus patients with or without acute coronary syndrome. Journal of Clinical and Diagnostic Research: JCDR, 10(12(
Blüher, M. (2011). Vaspin in obesity and diabetes: Pathophysiological and clinical significance. Endocrine, 41(2), 176-182.
Dimova, R., &Tankova, T. (2015). The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis. BioMed research international, 62-51.
Atya, H. B. Hassan, Z. A. Amin, A. I. & Ali, S. A. E.(2013). Vaspin concentration in obesity, impaired glucose tolerance and type 2 diabetes in Egypt. Advanced Research in Biological Sciences. 1(1), 6–13.
Zhang, B., Peng, W., Li, H., Lu, Y., Zhuang, J., Wang, K., Xu, Y. (2013). Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions. Clinical biochemistry, 46(15), 1520-1525.
Heiker, J. T., Klöting, N., Kovacs, P., Kuettner, E. B., Sträter, N., Schultz, S., . . .& Beck-Sickinger, A. G. (2017). Vaspin inhibits kallikrein 7 by serpin mechanism.Cell. Mol. Life Sci. Cellular and Molecular Life Sciences, 70(14), 2569-2583..
Gulcelik, N. E., Karakaya, J., Gedik, A., Usman, A., &Gurlek, A. (2009). Serum vaspin levels in type 2 diabetic women in relation to microvascular complications. European Journal of Endocrinology, 160(1), 65-70.
El-Mesallamy, H. O., Kassem, D. H., El-Demerdash, E., & Amin, A. I. (2011). Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus. Metabolism, 60(1), 63-70.
Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., &Paquot, N. (2014). Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes research and clinical practice, 105(2), 141-150.
Kulkarni, A. (2014). G468 Evaluation of Body Mass Index (BMI) Percentile cut-off Levels with Reference toInsulin Resistance: A Comparative Study on 100 Obese and Non-Obese Adolescents. Archives of Disease in Childhood, 99(Suppl 1), A194-A194.
Smith, G. I., Atherton, P., Villareal, D. T., Frimel, T. N., Rankin, D., Rennie, M. J., &Mittendorfer, B. (2008). Differences in muscle protein synthesis and anabolic 27 signaling in the postabsorptive state and in response to food in 65–80 year old men and women. PloS one, 3(3).
Huang, D., Refaat, M., Mohammedi, K., Jayyousi, A., Al Suwaidi, J., & Abi Khalil, C. (2017). Macrovascular complications in patients with diabetes and prediabetes. BioMed research international, 22-13.
Liu, P., Quinn, R. R., Lam, N. N., Al-Wahsh, H., Sood, M. M., Tangri, N., ... &Ravani, P. (2021). Progression and Regression of Chronic Kidney Disease by Age Among Adults in a Population-Based Cohort in Alberta, Canada. JAMA network open, 4(6(.
Contreras-Zentella, M. L., Sánchez-Sevilla, L., Suárez-Cuenca, J. A., OlguínMartínez, M., Alatriste-Contreras, M. G., García-García, N., ...&HernándezMuñoz, R. (2019). The role of oxidant stress and gender in the erythrocyte arginine metabolism and ammonia management in patients with type 2 diabetes. PloS one, 14(7(.
Mauvais-Jarvis, F., Manson, J. E., Stevenson, J. C., & Fonseca, V. A. (2017). Menopausal hormone therapy and type 2 diabetes prevention: evidence, mechanisms, and clinical implications. Endocrine reviews, 38(3), 173-188.
Mauvais-Jarvis F. (2018). Gender differences in glucose homeostasis and diabetes. Physiology & behavior, 187, 20–23.
Ambrož, M., de Vries, S. T., Vart, P., Dullaart, R. P., Roeters van Lennep, J., Denig, P., &Hoogenberg, K. (2021). Sex Differences in Lipid Profile across the Life Span in Patients with Type 2 Diabetes: A Primary Care-Based Study. Journal of clinical medicine, 10(8), 1775.
Tchernof, A., &Després, J. P. (2013). Pathophysiology of human visceral obesity: an update. Physiological reviews22-16.
Russo, G., Pintaudi, B., Giorda, C., Lucisano, G., Nicolucci, A., Cristofaro, M. R., ...&Manicardi, V. (2015). Age-and gender-related differences in LDL-cholesterol management in outpatients with type 2 diabetes mellitus. International Journal of Endocrinology, 22-13.
WHO., (2007). World Health Statistics 20-30.
Tchernof, A., &Després, J. P. (2013). Pathophysiology of human visceral obesity: an update. Physiological reviews20-11.
Hussain, A., Ali, I., Kaleem, W. A., & Yasmeen, F. (2019). Correlation between Body Mass Index and Lipid Profile in patients with Type 2 Diabetes attending a tertiary care hospital in Peshawar. Pakistan journal of medical sciences, 35(3), 591– 597.
Von Hafe, P. (2019). Gender differences in lipid profile and therapy. Rev Port Cardiol, 38(8), 571-2.
Okecka-Szymanska, J., Hübner-Wozniak, E., Piatkowska, I., &Malara, M. (2011). Effects of age, gender and physical activity on plasma lipid profile. Biomedical Human Kinetics, 3, 1.
Maric-Bilkan C. (2013). Obesity and diabetic kidney disease. The Medical clinics of North America, 97(1), 59–74.
Zulfania, A. K., Tahir Ghaffar, A. K., & Maria Arabdin, S. U. R. O. (2020). Correlation between serum leptin level and Body mass index (BMI) in patients with type 2 diabetes Mellitus. JPMA, 20-12
Sheth J, Shah A, Sheth F, Trivedi S, Nabar N, Shah N, et al. The association of dyslipidemia and obesity with glycated hemoglobin. Clini Diabetes Endocrinol. 2015 Dec;1(1):6:1-7.
Sisodia, R. K., &Chouhan, M. (2019). The study of correlation between body mass index and glycemic control-HbA1c in diabetes type 2 patients33-24.
Siricharoenthai, P., &Phupong, V. (2020). Diagnostic accuracy of HbA1c in detecting gestational diabetes mellitus. The Journal of Maternal-Fetal & Neonatal Medicine, 33(20), 3497-3500.
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