Prevalence of HAV IgM marker of Hepatitis A virus among patients of all Ages in Diyala province/Iraq

Authors

  • Noor Qasim Rashid
  • Ansam Dawod Salman

DOI:

https://doi.org/10.24237/ASJ.02.02.790B

Abstract

The most prevalent viral infection that causes hepatitis is hepatitis A virus (HAV), which continues to be a worldwide health issue for both developed and underdeveloped nations. By calculating the rate of HAV IgM positive, the current study sought to determine the prevalence of HAV infections among patients in the province of Diyala. In the present study, a total of 180 blood specimens were collected from patients, who referred to diagnostic individuals in Diyala Province, Iraq from October /2022 till Agust 2023. The presence of HAV in the specimens was investigated using ELISA technique. The results of the current study revealed that the overall positivity rate of HAV IgM was 13.3%.  HAV IgM positivity was higher among 1-2 years old group.  While, it was insignificantly higher among females compared to males (54.2%). Furthermore, HAV IgM positivity rate was insignificantly higher among Rurales compared to urbans (58.3%, 41.7%). Additionally the results showed that HAV IgM positivity rate among those used unsterilized water (70.8%) was significantly higher than that sterilized water (29.2%). Moreover, the results found that those with un vaccinated with HAV vaccine had significantly higher (79.2%) HAV IgM positivity rate. The present study founded that it is important to increase our knowledge about the frequency of HAV infections among patients and early diagnosis of HAV infections is essential in community for infection control.

References

I. P. Chatziprodromidou, M. E. Dimitrakopoulou, T. Apostolou, T. Katopodi E. Charalambous, A. Vantarakis, Hepatitis A and E in the Mediterranean: A systematic review, Travel Medicine and Infectious Disease, 102283(2022)

A. D. Salman, Evalution of anti-HAV antibodies (IgM) among children aged 1-5 years in Diyala governorate, (2018)

B. M. AL-aajem, Seroprevalence of helicobacter pylori and hepatitis A among children (Doctoral dissertation, College of medicine Seroprevalence of helicobacter pylori and hepatitis A among children Submitted to the Council of the College of Medicine, Diyala University), (2022)

World Health Organization. Hepatitis A. Updated February 2021. https://www.who.int/news-room/fact-sheets/detail/hepatitis-a

D. Mukherjee, M. R. Savaliya, V. Jaiswal, Organic , (2022)

E. Wilson, M. G. Hofmeister, S. McBee, J. Briscoe, E. Thomasson, R. H. Olaisen, , L. Haddy, Notes from the Field: hepatitis a outbreak associated with drug use and homelessness—West Virginia, 2018, Morbidity and Mortality Weekly Report, 68(14), 330(2019)

K. D. Johnson, X. Lu, D. Zhang, Adherence to hepatitis A and hepatitis B multi-dose vaccination schedules among adults in the United Kingdom: a retrospective cohort study, BMC Public Health, 19(1), 1-9(2019)

I. Abdullah, A. Goreal, Seroprevalence of anti-hepatitis A virus antibody in Iraq, East Mediterr Health J. 28(11),829-834(2022)

A. Chakravarti, T. Bharara, Epidemiology of hepatitis A: past and current trends. Hepatitis A and other associated hepatobiliary diseases, London: IntechOpen, 3-20(2020)

N. Iorio, S. John, Hepatitis A. In StatPearls [Internet]. StatPearls Publishing,(2022)

E. M. Tan, J. R. Marcelin, A. Virk, Pre-travel counseling for immunocompromised travelers: A 12-year single-center retrospective review. Infection, Disease and Health, 24(1), 13-22(2019)

M. A. Merzah, A. A. A. L. G. Mohammed, A. N. H. Al-Aaragi, M. Salim, Epidemiology of Viral Hepatitis from 2007 to 2016 in Karbala Governorate, Iraq, Journal of research in health sciences, 19(2), e00445(2019)

A. Ibrahim, G. Amer, Seroprevalence of anti-hepatitis A virus antibody in Iraq, EMHJ, 28 (11), 829-834(2022)

A. M. Turky, W. Akram, A. S. Al-Naaimi, A. R. Omer, J. Rawi, Analysis of acute viral hepatitis (A and E) in Iraq, Glob. J. Health Sci., 3(1):70–6(2011)

I. D. Ismail, H. I. Radhwan, Seroprevalence of Hepatitis A Virus (HAV) in Mosul City. Medico-legal Update, January-March, 20 (1),310-314(2020)

SH. Morshed, A. S. Saihood, Molecular Detection and Immunology Study of Hepatitis A Virus in Children under 6 Years Age, International Journal of Drug Delivery Technology,12 (1),217-220(2022)

A. B. Mohammad, L. Victor Hugo, N. Mandana, Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran, BMC Infectious Diseases,19,1027(2019)

M. Bharti, K. Anu, R. Janardhan, C. Aradhana, T. Jitendra, B. Shipra, H. N. Verma, Molecular characterization of hepatitis A virus from children hospitalized at a tertiary care centre in northwest India, Indian J Med Res., 147, 507-512(2018)

Y. Ahmet, Hepatitis A seroprevalence in Erzurum, Turkey, Annals of Agricultural and Environmental Medicine, 27 (3), 481–484(2020)

J. Meryem, R. Bisma, R. Harunor, L. Thao, R. Shafquat, Update on global epidemiology of viral hepatitis and preventive strategies, World Journal of Clinical Cases, 6(13), 589–599(2018)

R. Aggarwal, A. Goel, Hepatitis A: epidemiology in resourcepoor countries, Current opinion in infectious diseases, 28(5),488-496(2015)

T. Carmoi, S. Safiullah, E. Nicand, Risk of enterically transmitted hepatitis a, hepatitis E, and plasmodium falciparum malaria in Afghanistan, Clin Infect Dis., 48(12),1800(2009)

G. Fernanda, P. Francini, S. Rodrigo, R. Caroline, R. Fernando, Low occurrence of Hepatitis A virus in water samples from an urban area of Southern Brazil, Rev Inst Med Trop São Paulo, 60,e69(2018)

H. Yilmaz, A. Karakullukcu, N. Turan, Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA, BMC Infectious Diseases, 17,561(2017)

Z. Aşcı, S. Akgün, R. Keşli, N. Demirtürk, Seroprevalence rates of hepatitis A virus in different age groups in the province of Afyon Karahisar, Göztepe Tıp Derg., 29(2),94–8(2014)

A. M. Turky, W. Akram, A. S. Al-Naaimi, A. R. Omer, J. Rawi, Analysis of acute viral hepatitis (A and E) in Iraq, Glob. J. Health Sci., 3(1),70–6(2011)

M. Safiabadi, M. S. Rezaee-Zavareh, S. M. Alavian, Estimation of hepatitis a virus infection prevalence among eastern Mediterranean and Middle Eastern countries: a systematic review and pooled analysis., Hepat Mon., 17(2), e44695(2017)

R. Sukhyun, A. Sul, U. Jungwoo, Y. Joon, Hepatitis A Virus Infection from a Contaminated Tap of Ground Water Facility in a Neighborhood Park, Republic of Korea, Infect Chemother., 51(1), 62-66(2019)

R. A. Kozak, C. Rutherford, M. Richard-Greenblatt, N. E. Chau, A. Cabrera, M. Biondi, M. Smieja, Development and evaluation of a molecular hepatitis A virus assay for serum and stool specimens, Viruses, 14(1), 159-49(2022)

E. Catherine, J. Bryn, M. Katharine, Impact of Public Health Interventions on Drinking Water–Associated Outbreaks of Hepatitis A — United States, 1971–2017, MMWR, 68 (35), 766-770(2019)

M. A. Foster, M. G. Hofmeister, B. A. Kupronis, Increase in hepatitis A virus infections—United States, 2013–2018, MMWR Morb Mortal Wkly Rep, 68,413–5(2019)

CDC. Viral hepatitis surveillance, United States 2016. Atlanta, GA: US Department of Health and Human Services, (2017)

K. N. Ly, R. M. Klevens, Trends in disease and complications of hepatitis A virus infection in the United States, 1999–2011: a new concern for adults, J Infect Dis., 212,176–82(2015)

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Published

2024-04-30

How to Cite

Noor Qasim Rashid, & Ansam Dawod Salman. (2024). Prevalence of HAV IgM marker of Hepatitis A virus among patients of all Ages in Diyala province/Iraq. Academic Science Journal, 2(2), 51–61. https://doi.org/10.24237/ASJ.02.02.790B

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