Synthesis and Pharmacological Significance of Isoxazoline Derivatives: A Mini review
DOI:
https://doi.org/10.24237/ASJ.02.01.742CKeywords:
Heterocyclic compounds, Isoxazoline, Biological activities, Anticancer activity, Antioxidant activity.Abstract
Five-membered heterocycles, like isoxazolines, are an important class of compounds of bioorganic and pharmacological importance. They have been treated as useful intermediates for the transformation of a large number of bioactive molecules.
It was known that these classes of compounds have different biological activities. In this review, we discuss synthetic methods that are useful as building blocks for the synthesis of bioactive molecules and the medical application of isoxazoline systems.
The large number of studies described in this summary shows a wide range of pharmacological activities of isoxazole derivatives.
The pharmaceutical profiles of these new generations of isoxazoline would represent a fruitful matrix for the further development of the isoxazoline core, which could be a leading core for future developments to obtain safer and more effective therapies.
References
D. Patil, M. Chincholkar, and N. Dighade, Asian J. Chem.,15, 1, 450 (2003).
M. IMRAN, S, Khan, N. siddiqui, indian J. pharm. sci., 66, 4, 377-381 (2004)
K. Kumar and P. Jayaroopa, Int. J. Pharm. Chem. Biol. Sci, 3, 294–304 (2013)
A. Quilico, G. Alcontres, and P. Grünanger, Nature, 166, 4214, 226–227, (1950)
K. Kumar, M. Govindaraju, N. Renuka, and G. Vasanth Kumar, J. Chem. Pharm. Res., 7, 3, 250–257 (2015)
S. Bhosale, S. Kurhade, U. Prasad, V. Palle, and D. Bhuniya, Tetrahedron Lett., 50, 27, 3948–3951 (2009)
V. Govindappa, J. Prabhashankar, B. Khatoon, M. Nigappa, and A. Kariyappa, Der Pharma Chem., 4, 6, 2283–2287 (2012)
K. Umesha, K. Ajay Kumar, and K. Lokanatha Rai, Synth. Commun., 32, 12, 1841–1846 (2002)
A. Kumar and P. Jayaroopa, Int. J. Pharm. Chem. Biol. Sci., 3, 2, 294–304 (2013)
V. Kadnor, G. Pandhare, A. Gadhave, and B. Uphade, Rasayan J. Chem.,4, 2, 437–441 (2011)
G. Wang, Z. Chen, and X. Huang, Chinese Chem. Lett., 16, 8, 995 (2005)
A. Saad, M. Vaultier, and A. Derdour, Molecules, 9, 7, 527–534, (2004)
M. Mirzazadeh and G. Mahdavinia, E-Journal Chem., 9, 1, 425–429 (2012)
S. Gosavi, D. Nandal, and S. Pawar, Asian J. Chem., 31,12, 1760–1772 (2019)
N. Shah, A. Biradar, S. Habib, J. Dhole, M. Baseer, and P. Kulkarni, Der Pharma Chem., 3, 1, 167–171 (2011)
S. Dadiboyena and A. Nefzi, Tetrahedron Lett., 53, 16, 2096–2099, (2012)
H. Wang, R. Cheng , G. Wang, Y. Shi, J. Wang, H. Guo, L. Trigoura, Y. Xing, S. sun, Tetrahedron Lett., 61, 12, 151652 (2020)
Y. Lin, K. Zhang, M. Gao, Z. Jiang, J. Liu, Y. Ma, H. Wang, Org. Biomol. Chem., 17, 22, 5509–5513 (2019)
R. Sakly, H. Edziri, M. Askri, M. Knorr, K. Louven, C. Strohmann, M. Mastouri, J. Heterocycl. Chem., 54, 6, 3554–3564 (2017)
K. Kaur, M. Jain, R. Reddy, and R. Jain, Eur. J. Med. Chem., 45, 8, 3245–3264 (2010)
D. Mungra, M. Patel, D. Rajani, and R. Patel, Eur. J. Med. Chem., 46, 9, 4192–4200 (2011)
H. Pellissier, Chem. Rev., 113, 1, 442–524 (2013)
E. Dilli, M. Mastan, and T. Sobha, Der Pharm. Lett., 4, 5, 1431–1437 (2012)
M. Panchegowda, S. Nanjunda, K. Aryan, M. Sengottuvelan, D. Shivaramu, N. Chikkagundagal, G. Sethi, K. Sugahara, K. Subbegowda, BMC Chem. Biol., 12, (2012)
J. Khazir, P. Pal, D. Mahendhar, I. Hyder, S. Shafi, S. Sawant, G. Chashoo, A. Mahajan, M. Alam, A. Saxena, S. Arvinda, B. Gupta, H. Sampath Eur. J. Med. Chem., 63, 279–289 (2013)
M. Nikam, P. Mahajan, M. Damale, J. Sangshetti, S.. Dabhade, D. Shinde & C. Gill, Med. Chem. Res., 24, 9, 3372–3386, (2015)
V. Verma, Russ. J. Gen. Chem., 88, 12, 2628–2645 (2018)
K. Chikkula, Int. J. Pharm. Pharm. Sci., 9, 7, 13 (2017)
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 mohammed alwan
This work is licensed under a Creative Commons Attribution 4.0 International License.
