Relation between Renal Function and Insulin Resistance of Type 2 Diabetic Iraqi Patients
DOI:
https://doi.org/10.24237/ASJ.03.01.798BAbstract
Type 2 diabetes mellitus (T2DM) is a condition where the body's ability to regulate and utilize
glucose as fuel is compromised. As a result of this chronic ailment, excess sugar circulates in
the bloodstream. Thus, it can be described as a cluster of metabolic disorders that manifest
through factors like insulin resistance and give rise to various complications. These conditions
impact several physiological organs, leading to reduced efficiency in their functioning. The
objective of this study was to assess the level of insulin in patients with Type 2 diabetes mellitus
(T2DM) and to interpret the relationship between insulin resistance (HOMA-IR) and renal
function. The methods employed in this investigation were designed to achieve these specific
aims, seventy patients and twenty controls were involved for this study. The patients of T2DM
was divided into three group according to them eGFR, 20 stage I patients (G1), 25 stage II
diabetic patients (G2) and 25 stage III diabetic patients (G3). Insulin, fasting plasma glucose
(FBG), HbA1c, and renal function were measured in all subject. The study's findings indicated
that patients in Group 3 (G3) with elevated glomerular filtration rate (GFR) exhibited
significantly higher insulin levels (14.48 μIU/ml) and HOMA-IR values (8.66) compared to
other patients. Moreover, diabetic patients had significantly higher serum insulin levels than
those in the healthy control group (P<0.001). The diabetic group also demonstrated a marked
degree of insulin resistance compared to the healthy control group. Additionally, a negative
correlation was observed between HOMA-IR, eGFR, and Duration in the diabetic patients.
Conclusion: higher insulin levels and insulin resistance appear to contribute to the development
of chronic kidney disease (CKD).
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