Appraisal the Importance of Dehydroepiandrosterone, Metabolites, and Genus Aspergillus in Cancer research
DOI:
https://doi.org/10.24237/Keywords:
Biotransformation, Steroids, Metabolism, Aspergillus species, Anti-cancer agents.Abstract
Steroids are natural compounds found in animals, plants, fungi, and some bacteria. Microbial transformation plays a critical role in the biotransformation of steroids, enabling the production of compounds with high regional and spatial selectivity. Cancer remains one of the most significant scientific challenges, causing millions of deaths each year. Consequently, major research efforts are focused on discovering new therapies, particularly due to the emergence of certain fungi that exhibit anticancer properties, which could lead to innovative treatments. Metabolites, which are intermediate products of biochemical processes in living organisms, are essential for clinical diagnosis. Therefore, accurate detection of their concentrations is crucial.
In this work, I will describe an experiment published at the 1st International Karatekin Science and Technology Congress, held from September 1-3, 2022 in Çankırı, Turkey. The aim is to clarify the inputs, outputs, and processes to enhance the understanding of the key concepts discussed here. The experiment focused on incubating dehydroepiandrosterone (DHEA) with Aspergillus glaucus, which primarily resulted in the production of several hydroxylated metabolites. Discussing this experiment as one of the experiments that produces metabolites as a result of the biotransformation of steroids may have a major role in the development of promising treatments for cancer.
Downloads
References
[1] V. H. Ö. Semih Otles, Biotransformation in the production of secondary metabolites,(2021), DOI(https://doi.org/10.1016/B978-0-12-819485-0.00007-4)
[2] A. Cano-Flores, J. Gómez and R. Ramos, Biotransformation of Steroids Using Different Microorganisms,(2020), DOI(https://doi.org/10.5772/intechopen.85849)
[3] R. B. Clayton, R. H. Kluger, steroid, References & edit history, (2025), https://www.britannica.com/science/steroid
[4] R. B. C. Ronald, H. Kluger, steroid, (2024), https://www.britannica.com/science/steroid
[5] K. Valentová, Biotransformation of Natural Products and Phytochemicals: Metabolites, Their Preparation, and Properties, Int. J. Mol. Sci., 24(9), 8030 (2023), DOI(https://doi.org/10.3390/ijms24098030)
[6] E. Kozłowska, N. Hoc, J. Sycz, M. Urbaniak, M. Dymarska, J. Grzeszczuk, E. Kostrzewa-Susłow, Ł. Stępień, E. Pląskowska & T. Janeczko, Biotransformation of steroids by entomopathogenic strains of Isaria farinosa, Microb Cell Fact 17, 71 (2018), DOI(https://doi.org/10.1186/s12934-018-0920-0)
[7] RD. Beger, A review of applications of metabolomics in cancer, Metabolites, 3(3):552-74(2013), DOI(https://doi.org/10.3390/metabo3030552)
[8] N. N. Tamzi, M. M. Rahman, & S. Das, Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy, International Journal of Translational Medicine, 4(4), 740-781(2024), DOI(https://doi.org/10.3390/ijtm4040051)
[9] A. G. Schwartz, Dehydroepiandrosterone, Cancer, and Aging, Aging and disease, 13(2), 423-432(2022), DOI(https://doi.org/10.14336/AD.2021.0913)
[10] I. Giacomini, M. Montopoli, Editorial: Metabolism Meets Function: The Multifaced Role of Metabolism in Cancer, Front Oncol., 4(12),906421(2022), DOI(https://doi.org/10.3389/fonc.2022.906421)
[11] S. Charoensin, P. Pothacharoen, O. Wanachewin, P. Kongtawelert, M. Suttajit, Functional foods in improving bone health during aging, chapter 15, (Elsevier, 2023), DOI(https://doi.org/10.1016/B978-0-323-90581-7.00009-8)
[12] E. Kozłowska, J. Sycz, and T. Janeczko, Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic Strain Isaria farinosa KCh KW1.1., Int. J. Mol. Sci. , 23(13), 7015(2022), DOI(https://doi.org/10.3390/ijms23137015)
[13] T. A. Fedotcheva, M. E. Uspenskaya, D. N. Ulchenko, and N. L. Shimanovsky, Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application, Pharmaceuticals , 17(9), 1186 (2024), DOI(https://doi.org/10.3390/ph17091186)
[14] T. Hosseinabadi, H. Vahidi, B. Nickavar, F. Kobarfard, Biotransformation of Progesterone by Whole Cells of Filamentous Fungi Aspergillus brasiliensis, Iran J Pharm Res., 14(3),919-24(2015)
[15] F. S. Youssef, E. Alshammari, and M. L. Ashour, Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling, Int. J. Mol. Sci. , 22(4), 1866(2021), DOI(https://doi.org/10.3390/ijms22041866)
[16] C. Paulussen , J. E. Hallsworth, S. Álvarez‐Pérez, W. C. Nierman, P. G. Hamill, D. Blain, H. Rediers, B. Lievens, .Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species, Microb Biotechnol, 7, 10(2), 296–322(2016), DOI(https://doi.org/10.1111/1751-7915.12367)
[17] R. M. A. Al-ani, Dehidroepiandrosteron bileşiğinin aspergıllus glaucus küfü ile biyotransformasyonu = Bıiotransformation of dehydroepiandrosterone by aspergıllus glaucus, (2023)
[18] K. K. Michael Miller, N. Al-Rayyan, M. M. Ivanova, K. A. Mattingly, S. L. Ripp, C. M. Klinge, R. A. Prough, DHEA metabolites activate estrogen receptors alpha and beta, Steroids, 78(1), January, Pages 15-25(2013), DOI(https://doi.org/10.1016/j.steroids.2012.10.002)
[19] A. G. Schwartz, Dehydroepiandrosterone, Cancer, and Aging, 13(2), 423–432(2022), DOI(https://doi.org/10.14336/AD.2021.0913)
[20] R. T. Chatterton, Functions of dehydroepiandrosterone in relation to breast cancer, Steroids, 179, March, 108970(2022), DOI(https://doi.org/10.1016/j.steroids.2022.108970)
[21] Li-Hua Huang, Juan Li, Gong Xu, Xiang-Hua Zhang, Yang-Guang Wang, Ye-Lin Yin, Hong-Min Liu, Biotransformation of dehydroepiandrosterone (DHEA) with Penicillium griseopurpureum Smith and Penicillium glabrum (Wehmer) Westling, Steroids, 75(13–14), 1039-1046(2010), DOI(https://doi.org/10.1016/j.steroids.2010.06.008)
[22] E. Noman, M. M. Al-Shaibani, M. A. Bakhrebah, R. Almoheer, M. Al-Sahari, A. Al-Gheethi, R. Mohamed, R. M. S., Y. Q. Almulaiky, & W. H. Abdulaal, Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi, Journal of Fungi, 7(6), 436(2021), DOI(https://doi.org/10.3390/jof7060436)
[23] H. Jangid, S. Garg, P. Kashyap, A. Karnwal, A. Shidiki, and G. Kumar,) Bioprospecting of Aspergillus sp. as a promising repository for anti-cancer agents: a comprehensive bibliometric investigation, Front. Microbiol., 15, 1379602(2024), DOI(https://doi.org/10.3389/fmicb.2024.1379602)
[24] E. Kozłowska, M. Urbaniak, N. Hoc, Cascade biotransformation of dehydroepiandrosterone (DHEA) by Beauveria species, Sci Rep 8, 13449(2018), DOI(https://doi.org/10.1038/s41598-018-31665-2)
Downloads
Published
Issue
Section
License
Copyright (c) 2025 CC BY 4.0
This work is licensed under a Creative Commons Attribution 4.0 International License.
