Synthesis, Characterization and Cytotoxicity Activity Study of Some Indole Derivatives

Abstract

In this study, several new pyrazoline made from indole derivative were synthesized. pyrazoline
derivatives are created via the condensation reaction of the chalcone derivatives (A1-A4) with
2,4-dinitrophenylhydrazine produce pyrazoline derivatives (A5-A8). The structure of
substances was verified and described using the spectroscopic techniques (FT-IR and 1HNMR),
the reactions were followed by thin layer chromatography (TLC) to ensure that the
preparation of these compounds is complete and their purity. Target compounds cytotoxic
effects at different concentrations on the human breast cancer cell line MCF7 were investigated.
The results showed that these chemicals had potential cytotoxic activity against the MCF7 cell
line.