Synthesis and biological evaluation for some metal complexes with a new ligand (E)-3-(((2-amino-4-methylphenyl)imino)methyl)-4H-chromen-4-one
DOI:
https://doi.org/10.24237/ASJ.03.01.753CAbstract
Complexes of Co(II), Ni(II), Cu(II) Zn(II), and Cd (II) with the ligand 3-(((2-amino-4-methylphenyl)imino)methyl)-4H-chromen-4-one derived 3-formyl chromone with 4-methyl-O-phenylenediamine were synthesized and characterized by elemental analysis, FTIR, electronic spectra, magnetic moment and molar conductance. The prepared complexes have the general formulae [M(C17H14N2O2)2]Cl2, M = Co(II), Ni(II), Cu(II) and Zn(II) except complex of cadmium it have the formulae [Cd(C17H14N2O2)Cl]Cl. The data which obtain from analysis indicate that the complexes have octahedral geometry around the metal center except cadmium complex exhibit tetrahedral geometry. Two types of bacteria (E.coli ) and (S. aureus ) used to estimate the biological activities of complexes .
References
P. Arora, V. Arora, H. S. Lamba, D. Wadhwa, Importance of heterocyclic chemistry: a
review, International Journal of Pharmaceutical Sciences and Research, 3(9),
(2012),DOI(http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).2947-54)
P. K. Shukla, A. Verma, P. Mishra, Significance of nitrogen heterocyclic nuclei in the
search of pharmacological active compounds, New perspective in agricultural and
human health, (Bharti publication. New Delhi, 2017), 100-126
T. Qadir, A. Amin, P. K. Sharma, I. Jeelani, H. Abe, A review on medicinally important
heterocyclic compounds, The Open Medicinal Chemistry Journal, 16(1),1-32(2022),
DOI(http://dx.doi.org/10.2174/18741045-v16-e2202280)
B. Eftekhari-Sis, M. Zirak, A. Akbari, Arylglyoxals in synthesis of heterocyclic
compounds, Chemical Reviews, 113(5), 2958-3043 (2013),
DOI(https://doi.org/10.1021/cr300176g)
T. B. Fitzpatrick, L. M. Chapman, The importance of thiamine (vitamin B1) in plant
health: From crop yield to biofortification, Journal of Biological Chemistry, 295(34),
-12013(2020), DOI(https://doi.org/10.1074/jbc.rev120.010918)
C. Foti, G. Calogiuri, E. Nettis, A. De Marco, L. Stingeni, K. Hansel, A. Barbaud,
Allergic contact dermatitis from vitamins: A systematic review, Health Science
Reports, 5(6), e766(2022),DOI(https://doi.org/10.1002/hsr2.766)
P. Tandon, Q. Jin, L. Huang, A promising approach to enhance microalgae productivity
by exogenous supply of vitamins, Microbial cell factories, 16(1), 1-13(2017),
DOI(https://doi.org/10.1186/s12934-017-0834-2)
A. M. Rayar, N. Lagarde, C. Ferroud, J. F. Zagury, M. Montes, M. Sylla-Iyarreta Veitia,
Update on COX-2 selective inhibitors: Chemical classification, side effects and their use
in cancers and neuronal diseases, Current topics in medicinal chemistry, 17(26), 2935-
(2017), DOI(https://doi.org/10.2174/1568026617666170821124947)
Y. Xu, Q. L. Mi, Y. K. Li, W. L. Zeng, Q. Gao, C. M. Song, J. Wang, Three new antitobacco mosaic virus prenyl chromone derivatives from Cassia nomame,
Heterocycles, 98(3), 444-450(2019), DOI(https://doi.org/10.3987/com-19-14041)
A. A. Jarullah, F. L. Faraj, H. S. Lateef, N. A. Imran, S. M. Salih, Synthesis a new series
of complexes from the ligand (LOH), In: AIP Conf. Proc. 2475, 040019-1-040019-
(2023), DOI(https://doi.org/10.1063/5.0105263)
A. M. Abu-Dief, I. M. Mohamed, A review on versatile applications of transition metal
complexes incorporating Schiff bases, Beni-suef University Journal of Basic and
Applied Sciences, 4(2), 119-133(2015),
DOI(https://doi.org/10.1016/j.bjbas.2015.05.004)
O. E. Sherif, El-Fattah, M. Hussein, M. M. El-Ajily, Characterization of transition metal
ion chelates with 8-(arylazo) chromones using thermal and spectral techniques, Journal
of Thermal Analysis & Calorimetry, 74(1), (2003),
DOI(https://doi.org/10.1023/A:1026390105986)
N. D. Resen, B. F. Abbas, T. M. Alkhaisy, N. Majed, Structural study and antimicrobial
evaluation of some transition metal complexes with 3-(2-amino-4-methylphenyl)-2-
thioxo-2, 3-dihydroquinazolin-4 (3H)-one, Periodicals of Engineering and Natural
Sciences, 8(3), 1548-1554(2020)
J. E. Philip, S. A. Antony, S. J. Eeettinilkunnathil, M. P. Kurup, M. P. Velayudhan,
Design, synthesis, antimicrobial and antioxidant activity of 3-formyl chromone
hydrazone and their metal (II) complexes, Inorganica Chimica Acta, 469, 87-97(2018),
DOI(https://doi.org/10.1016/j.ica.2017.09.006)
J. E. Philip, M. Shahid, M. P. Kurup, M. P. Velayudhan, Metal based biologically active
compounds: design, synthesis, DNA binding and antidiabetic activity of 6-methyl-3-
formyl chromone derived hydrazones and their metal (II) complexes, Journal of
Photochemistry and Photobiology B: Biology, 175, 178-191(2017),
DOI(https://doi.org/10.1016/j.jphotobiol.2017.09.003)
N. H. Al-Shaalan, Synthesis, characterization and biological activities of Cu (II), Co (II),
Mn (II), Fe (II), and UO2 (VI) complexes with a new Schiff base hydrazone: OHydroxyacetophenone-7-chloro-4-quinoline hydrazine, Molecules, 16(10), 8629-
(2011), DOI(https://doi.org/10.3390/molecules16108629)
B. Geeta, K. Shravankumar, P. M. Reddy, E. Ravikrishna, M. Sarangapani, K. K. Reddy,
V. Ravinder, Binuclear cobalt (II), nickel (II), copper (II) and palladium (II) complexes
of a new Schiff-base as ligand: Synthesis, structural characterization, and antibacterial
activity, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 77(4),
-915(2010), DOI(https://doi.org/10.1016/j.saa.2010.08.004)
B. M. Sarhan, S. M. Lateef, E. J. Waheed, Synthesis and characterization of some new
metals complexes of [N-(3-acetylphenylcarbamothioyl) -4- methoxy- benzamide,
Diyala Journal for Pure Sciences, 12( 1), 28-42(2016)
W. H. Mahmoud, N. F. Mahmoud, G. G. Mohamed, A. Z. El-Sonbati, A. A. El-Bindary,
Synthesis, spectroscopic, thermogravimetric and antimicrobial studies of mixed ligands
complexes, Journal of Molecular Structure, 1095, 15-25(2015),
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