Synthesis, Characterization and Antibacterial Activity for 2-(1, 1-dimethyl- 1, 3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde Indole

Abstract

This study examines a number of indole derivatives (C2-C5), were successfully prepared by
the condensation reaction of diamine derivatives such as (3, 4-diaminobenzoic acid, benzene-
1, 2-diamine, urea and thiourea) with 2- [1, 1-dimethyl-1, 3-dihydro-2H-benzo[e]indol-2-
ylidene] malonaldehyde [C1]. They produced when 1, 1, 2-trimethylbenz[e] indole and POCl3
were combined in the presence of dimethyl forma mide (DMF). Compounds (C2-C3) were
prepared by refluxing of compound (C1) with (3, 4-diaminobenzoic acid, benzene-1, 2-
diamine), while compounds (C4, C5) were synthesized through the reaction of compound (C1)
with urea and thiourea respectively in the presence of hydrochloric acid [HCI] as catalyst,
spectroscopic methods such as (FT-IR and nuclear resonance spectroscopy 1H-NMR) were
used to confirm the compounds' purity. The agar well diffusion method was used to test new
compounds for their, antibacterial activity against E. coli and S. aureus, and the findings were
inconsistent.