Synthesis, Characterization and Study of Biological Activity of Some New Schiff Bases

Authors

DOI:

https://doi.org/10.24237/

Keywords:

glutaric acid, Schiff bases, bis(4-formylphenyl) glutarate , bis(4-(chlorocarbonyl)phenyl) glutarate.

Abstract

            In the present study, ( Schiff's bases 6a - 6e) and  (new amids derivatives 6f - 6j) have been synthesized .

The glutaroyl chloride(2) has been prepared by the reacting of glutaric acid and thionyl chloride in presence of (DMF) . The new compound bis(4-formylphenyl) glutarate (3) has been Synthesized from reaction of one mole of glutaroyl chloride and two moles of 4-hydroxybenzaldehyde . Compound 4,4'-(glutaroylbis(oxy))dibenzoic acid (4) was Synthesized from one mole of glutaroyl chloride and two moles of 4-hydroxybenzoic acid, while compound bis(4-(chlorocarbonyl)phenyl) glutarate (5) was prepared from 4,4'-(glutaroylbis(oxy))dibenzoic acid and Thionyl chloride . Then Schiff's bases 6a - 6e that prepared from the reaction of compound no:3 and derivatives amine in EtOH. Amids 6f - 6j  were  synthesized from the reaction of previous acid chloride  (5) and derivatives amine in  py. and DMF . All the prepared compounds have been characterized as usual by the spectral methods (which including FT-IR , H-NMR (6a , 6d and 6i) besides TLC . Techniques and the melting points were recorded . Then the antibacterial studies were checked against two types of bacterial . we discovered that the compounds 6a, 6d, 6h, and 6i showed high growth against all bacteria of E_ coli and staphylococcus aureus basides  psudomonas aeruginosa .

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Published

2025-04-30

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Synthesis, Characterization and Study of Biological Activity of Some New Schiff Bases. (2025). Academic Science Journal, 3(2), 166-183. https://doi.org/10.24237/