1A and 4A Genotypes of Hepatitis C Virus and Their Influence on Some Biochemical and Hematological Changes in Infected Iraqi Patient

Authors

  • DHUHA SABAH National Center of Hematology, Mustansiriyah University, Baghdad, Iraq.
  • Aliyah Farhan Salman Al-Mustansiriya University
  • Farhan Salman
  • Muhana Oweed
  • sara thamer

DOI:

https://doi.org/10.24237/04.01.724

Keywords:

1A genotype, , 4A genotype,, Hepatitis C virus, anti- HCV Abs, hepatitis infection, ALT liver enzyme and AST liver enzyme , Hematological parameters, , Liver enzymes.

Abstract

Hepatitis C Virus (HCV) causes about 70 million chronic infections, posing a serious threat to global health. This study aimed to determine the most common HCV genotypes and their effects on liver enzyme and hematological parameter concentrations in Iraqi patients. This study examined 100 untreated HCV cases (infected Iraqi patients; age mean±SD: 41.99±16.78 years) and 100 uninfected HCV cases (control group; age mean±SD: 39.64±13.55 years). The study was conducted from January 2024 to October 2024 at Al-Yarmouk Teaching Hospital in Baghdad, Iraq Viral genotypes were determined by real-time PCR. Statistical analysis showed a significant increase in hematological parameters, with hemoglobin and PLT levels being significantly higher in infected patients compared to the control group (p<0.05). Similarly, liver enzymes were also increased in Iraqi patients infected with genotypes 1A and 4A of hepatitis C virus (HCV), Patients with the 4A genotype were older on average and showed a greater influence on laboratory parameters, possibly due to a weakened immune response associated with advanced age. In addition, Iraqi patients infected with HCV showed a higher prevalence of the 1A genotype (57%) compared to the 4A genotype (43%). This paper contributes to understanding the relationship between genotypes of HCV and changes in biochemical and hematological parameters by providing accurate information that helps in making evidence-based medical decisions that meet the patients' needs more accurately and effectively.

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Author Biographies

  • DHUHA SABAH, National Center of Hematology, Mustansiriyah University, Baghdad, Iraq.

    Asst. lect. Dhuha Sabah Hasan is Assistant luctuer at the National Center for Hematology, Al-Mustansiriya University, Baghdad, Iraq. She holds a Bachelor of Science degree in Chemistry from the University of Diyala/College of Science, and a Master of Science degree in Chemistry/Materials Chemistry from the Polytechnic University of Romania. Her research areas include biomaterials, biochemistry, and materials science. She has published numerous scientific papers in local and international conferences and journals. She can be contacted via email at: dhuha.sabah@uomustansiriyah.edu.iq

  • Aliyah Farhan Salman , Al-Mustansiriya University

    Dr. Aliyah Farhan Salman is an Assistant Professor at the National Center for Research and Treatment of Blood Diseases at Al-Mustansiriya University, Iraq. She holds a Bachelor's degree in Chemistry and a Master's degree from the University of Baghdad, Iraq. She also holds a PhD in Clinical Chemistry from the College of Medicine at Al-Mustansiriya University. She has published numerous scientific papers in local and international conferences and journals. She can be contacted via email at aliyah_farhan@uomustansiriyah.edu.iq.

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Published

2026-01-30

Issue

Vol. 4 No. 1 (2026): Current Issue: Advances in Science

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Articles

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Copyright (c) 2026 CC BY 4.0

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

SABAH, D., Salman, A. ., Farhan , A. ., Oweed, M. ., & thamer, sara. (2026). 1A and 4A Genotypes of Hepatitis C Virus and Their Influence on Some Biochemical and Hematological Changes in Infected Iraqi Patient. ٍِASJ - Academic Science Journal, 4(1), 1-6. https://doi.org/10.24237/04.01.724

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